We have been investigating S. aureus host-pathogen interactions in collaboration with other laboratories. Most prominently with Dr. William Nauseef (Iowa) and in the context of S. aureus interactions with human neutrophils.  Our primary interest is understanding the roles of S. aureus secreted enzymes.  We have investigated the function of extracellular proteases, nucleases, hyaluronidases, and phospholipases during infection.